R&D

Regenerative Therapeutics

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Atopic Dermatitis

  • ExoCoBio has published the world's first paper on the effect of exosomes on atopic dermatitis, proving that ExoSCRT Exosome is a competitive new drug candidate.
    (Cho et al. Stem Cell Research & Therapy / 2018)

Atopic Dermatitis

Long-lasting chronic dermatitis. Usually occurs from 2 to 3 months of age,
and is caused by a variety of factors, including genetics,
immunological abnormalities, and malfunction of the skin barrier.

ExoCoSCRT Exosome
  • For the first time in the world ExoCoBio has proved that exosome can reduce atopic dermatitis.
  • It has been also demonstrated that ExoSCRT exosome can relieve inflammation and itching, as well as strengthen the skin barrier.
Multiple functions of exosome proved in various animal models!
  • 01. Inflammation model (intrinsic)
    Relieving of atopic dermatitis anti-inflammatory effects
  • 02. Skin barrier model (extrinsic)
    Regeneration of skin barrier, relieving of atopic dermatitis, and anti-inflammatory effects
  • 03. Spontaneous AD model
    Curing atopic dermatitis in dogs
Multiple effects of ExoSCRT Exosome

Exosome-based biomedicine is a promising alternative to intractable diseases

Atopic dermatitis inflammation improvement effect
  • Concentration-dependent ExoSCRT Exosome can ease atopic dermatitis

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[Ref. Cho et al. Stem Cell Research & Therapy (2018) 9:187]

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Skin barrier reconstruction for relieving AD
  • ExoSCRT-exosome promotes biosynthesis of ceramide, a vital material for the skin barrier
    (Increase ceramide and facilitate ceramide biosynthesis)
  • Skin barrier, regenerated with ceramide, suppresses external inflammatory substances

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[Ref. Cells 2020,9,680;doi:10.3390/cells9030680]

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